发明名称 |
CEFUROXIMAXETIL I AMORF FORM, FORFARANDE FOR FRAMSTELLNING DERAV OCH KOMPOSITION INNEHALLANDE DENNA |
摘要 |
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration. Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described. Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine. |
申请公布号 |
SE453195(B) |
申请公布日期 |
1988.01.18 |
申请号 |
SE19830004208 |
申请日期 |
1983.07.29 |
申请人 |
GLAXO GROUP LTD |
发明人 |
H A * CRISP;J C * CLAYTON;L G * ELLIOTT;E M * WILSON |
分类号 |
C07D501/00;A61K;A61K31/19;A61K31/325;A61K31/34;A61K31/54;A61K31/545;A61K31/546;A61P31/04;C07C;C07D;C07D501/02;C07D501/04;C07D501/12;C07D501/20;C07D501/24;C07D501/34;C07D501/46;(IPC1-7):C07D501/34 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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