| 摘要 |
<p>NEW MATERIAL:A compound of formula I [Q is N or CR<4> (R<4> is H or halogen); n is 1-6; R<1> is H or (substituted) lower alkyl; R<2> is lower alkyl or lower cycloalkyl; R<3> is organic residue bonded through O, S or NH, amino or nitrogen- containing heterocyclic group]. EXAMPLE:7-[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-{N, N-dime thyl-N-[3-(1,2,3-thiazol-5-yl)thiopropyl]ammoniomethyl}-3-cephem-4-car boxylate. USE:An antibacterial agent effective even against clinically separated stock bacteria such as Citrobacter. PREPARATION:For example, a compound of formula II (R<9> is H or protecting group) is reacted with a compound of formula III (R<10> is R<3>, etc.) usually in a solvent such as methylene chloride preferably at -40-+40 deg.C for 5min-2hr.</p> |
