发明名称 |
POLYPEPTIDE COMPETITOR FOR IMMUNOGLOBULIN E |
摘要 |
A competitor for human Immunoglobulin E (IgE) comprises a polypeptide which has a core sequence of seventy-six amino acids which is shown, together with the corresponding DNA sequence coding therefor, in Fig. 2. This amino acid sequence, numbered 1 to 76, corresponds to amino acids 301 to 376 of the epsilon heavy chain of IgE. The polypeptide may also include additional short sequences at the beginning and/or end of the core sequence which are physiologically harmless and do not contribute to the ability of the core sequence to bind compete with native IgE for the high-affinity receptor sites on human cells. The polypeptide is indicated for the treatment of Type I hypersensitivity reactions such as hay fever. The polypeptide may be produced synthetically or by expression from Escherichia coli containing a plasmid having a DNA segment coding for the polypeptide. |
申请公布号 |
WO8800204(A2) |
申请公布日期 |
1988.01.14 |
申请号 |
WO1987GB00466 |
申请日期 |
1987.07.02 |
申请人 |
RESEARCH CORPORATION LIMITED |
发明人 |
GOULD, HANNAH, J.;HELM, BIRGIT, A. |
分类号 |
G01N33/53;A61K38/00;A61P37/08;C07H21/04;C07K14/00;C07K16/00;C12N1/20;C12N15/00;C12N15/09;C12P21/02;C12R1/19;G01N33/563;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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