| 摘要 |
<p>NEW MATERIAL:The compound of formula I (R1 is H or protecting group of alpha-amino of an amino acid; R2 is side chain of amino acid; X is H, halogen or alkyl; R3 are alkyl; Y is halogen, perchloric acid, alkylsulfuric acid, etc.). EXAMPLE:t-Butyroxycarbonylphenylalanine p-dimethylsulfoniophenyl ester methyl sulfate. USE:Useful as a water-soluble active ester for peptide synthesis. PREPARATION:The compound of formula I can be produced from a p-dialkyl- sulfoniophenol compound of formula II and an amino acid derivative of formula III by mixed acid anhydride process or by condensing the above compound with dicyclohexyl carbodiimide.</p> |
