| 摘要 |
<p>NEW MATERIAL:The titled compound shown by the formula I (R is hydroxyl or H; one of R1 and R2 is H, and the other is 1-6C alkyl) and its acid addition salt. EXAMPLE:1-N-( L-4-Amino-2-hydroxybutyryl )-6'( R )-C-methyl-3'-deoxykanamycin B. USE:An antibacterial agent effective against a resistant bacterium, sensitive bacterium, etc. PROCESS:An amino group of a 6'-C-alkyl-3'-deoxykanamycin B or 6'-C-alkyl-3', 4'-dideoxykanamycin B shown by the formula II or their derivative wherein 4 amino groups except the amino group in the 1st position, and, if necessary, hydroxyl groups, are at least partially protected by protecting groups is acylated by L-4- amino-2-hydroxybutyric acid. The protecting groups of the reaction product are removed conventionally to give a compound shown by the formula I.</p> |
