PHARMACEUTICAL BRONCHODILATION COMPOSITION OF A SHORT PEPTIDE TERMINATING WITH A PROLINE-NHZ GROUP

摘要

The peptides of the formula X - Tyr - X<2> - Gly - Phe(4NO2) - Pro - NH2 wherein X is hydrogen or an amidino group and X<2> is D-S-methylmethionyl or D-arginyl, together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstriction in mammals. The said compounds have application in the palliation of conditions characterised by such a state, in particular asthma in human beings.