| 摘要 |
PURPOSE:An external preparation suppressing melanin formation useful against chromatodermatosis such as chloasma, etc., containing an extracted solution of placenta and ergothioneine as active ingredients. CONSTITUTION:An external preparation containing an extracted solution of placenta (e.g. extracted solution of human placenta) and ergothioneine as active ingredients. Continuous internal use of vitamin and use of ointment containing ultraviolet light absorber or external preparation containing decoloring agent as external therapy are known as a therapy against chromatodermatosis such as chloasma, etc., but no therapy has provides satisfactory effects. Ergothioneine and the extracted solution of placenta individually show inhibitory action on melanin formation, exhibit different action mechanisms and it is considered that improved melanin suppressing effects are obtained by the synergistic effects of both the substances. The amounts of the active ingredients to show sufficient effects are 0.01-5wt% based on the whole drug of ergothionine and 0.1-10wt% extracted solution of placenta. |
