| 摘要 |
PURPOSE:The titled drug useful as an anticoagulant, preventing coagulation with a small amount, having high safety, comprising S-(1,2-dicarboxyethyl) glutathione or a salt thereof as an active ingredient. CONSTITUTION:An anticoagulant containing S-(1,2-dicarboxyethyl)glutathione shown by the formula or a salt thereof as an active ingredient. The compound shown by the formula is a peptide existing in organisms and is useful as an anticoagulant since the compound prevents coagulation with a smaller amount than that of ethylenediaminetetraacetic acid, oxalic acid, citric acid or salts thereof generally used as anticoagulants. Since the compound is a peptide having low toxicity, the compound can be used also as a preventive or remedy for thrombosis. Since the compound occurs in yeast or bovine crystalline lens, the compound is obtained by extraction, purification and isolation form the yeast or bovine crystalline lens or reacting an aqueous solution of maleic acid with glutathione under heating. |
