| 摘要 |
<p>Tetrazines of the formula: <CHEM> wherein R<1> represents cycloalkyl, optionally substituted alkyl, alkenyl or alkynyl, A<1> represents nitrogen or -CR<3>= wherein R<3> represents hydrogen or a substituent, A<2> represents nitrogen or, when A<1> represents nitrogen, A<2> represents nitrogen or a group -CR<3>= as hereinbefore defined, Z<1> represents oxygen or sulphur, and R<2> represents a cyano or azidocarbonyl group or a group of the formula -COZ<2>R<9>, -CONHOR<9>, -CONHNR<9>R<1><0>, -CONHNHCOOR<9>, -CONHNHCONHR<9> -COCR<1><1>=N2, -CONHR<1><2> or -CON=S(O)R<1><3>R<1><4> wherein Z<2> is oxygen or sulphur and R<9> and R<1><0> each represents hydrogen, alkyl which may carry an optionally substituted phenyl substituent, or represents optionally substituted phenyl, R<1><1> represents hydrogen or alkyl, and R<1><2> represents optionally substituted alkyl and R<1><3> and R<1><4> each represent alkyl, and when R<1>, R<2>, or R<3> represents or contains an acidic group, salts thereof are useful as pharmaceuticals; processes for their preparation and new intermediates are described.</p> |
