Fowl bone mineralization with 28-NOR 1 alpha -hydroxyvitamin D2 analogs

摘要

The invention provides, as novel vitamin D derivatives, analogs of vitamin D2 compounds which lack the 24-methyl substituent and are identified as 1 alpha -hydroxy-28-norvitamin D2 and 1 alpha ,25-dihydroxy-28-norvitamin D2. The compounds of the invention are characterized by unexpectedly high vitamin D-like activity as well as a novel activity pattern. Because of such activity they would find ready application as substitutes for vitamin D or various of the known vitamin D metabolites in their various application for the treatment of calcium disorders.