发明名称 |
FORFARANDE FOR FRAMSTELLNING AV ETT MAGNESIUMHALOGENIDKOMPLEX AV 2-ARYLPROPIONSYROR OCH ANVENDNING AV DETTA FOR FRAMSTELLNING AV 2-ARYLPROPIONSYROR |
摘要 |
Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance. |
申请公布号 |
SE453093(B) |
申请公布日期 |
1988.01.11 |
申请号 |
SE19820001458 |
申请日期 |
1982.03.09 |
申请人 |
SYNTEX PHARMACEUTICALS INTERNATIONAL LTD |
发明人 |
G J * MATTHEWS;R A * ARNOLD |
分类号 |
C07B31/00;C07B37/04;C07C51/00;C07C51/353;C07C53/19;C07C57/30;C07C57/58;C07C59/64;C07C63/24;C07C65/24;C07C67/00;C07F3/02;(IPC1-7):C07F3/02;C07C57/26 |
主分类号 |
C07B31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|