Process for preparing nitrofurylbenzimidazoles and pharmaceutical compositions having antimycotic, antibacterial and antitubercular activities containing same.

摘要

Nitrofurylbenzimidazoles having general formula (I) <CHEM> wherein R is hydrogen; * straight or branched C1-C12 alkyl; halogen; nitro group; or halogen-substituted C1-C4 lower alkyl are obtained with high yields by condensing an o-phenylendiamine having general formula (II) <CHEM> wherein R has the above-identified meaning. with 5-nitro-2-furaldehyde in the presence of a ferricyanide of the alkaline or alkaline-earth metals. Nitrofurylbenzimidazoles (I) are endowed with potent antimycotic, antibacterial and antitubercular activities and are suitable for being compounded into pharmaceutical compositions administrable via the systemic route.