Recombinant alveolar surfactant protein.

摘要

The complete coding sequence and amino acid sequences for both canine and human 10K alveolar surfactant proteins (ASP) are disclosed; clones encoding variants of the SP-18 and SP-5 forms of human protein are disclosed. Methods and vectors for obtaining these proteins in recombinant form are also described. An improved method for purification of the 32K protein takes advantage of its carbohydrate affinity.Pharmaceutical compositions in the treatment of respiratory deficiency syndromes use the 10K proteins with or without the 32K form.