发明名称 |
Process for separation of syn and anti oxime isomers of cephalosporin-compounds |
摘要 |
A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers. The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7 beta -position, and of acids corresponding to this 7 beta -side chain, is described.
|
申请公布号 |
US4717768(A) |
申请公布日期 |
1988.01.05 |
申请号 |
US19840648382 |
申请日期 |
1984.09.07 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
ROBINSON, COLIN;EASTLICK, DAVID T.;BOWNASS, AUDREY J. |
分类号 |
C07D277/30;C07D307/54;C07D501/04;C07D501/12;C07D501/14;C07D501/20;C07D501/34;C07D501/46;(IPC1-7):C07D501/12;A61K31/545 |
主分类号 |
C07D277/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|