7_H thieno[2,3-a]quinolizines, useful as alpha 2-andrenoceptor antagonist

摘要

The invention concerns thienoquinolizines of general formula (I) <IMAGE> (I) and their pharmaceutically acceptable acid addition salts. In the formula R1 is hydrogen or lower alkyl and R2 is lower alkyl, halo(lower)alkyl, -A-NR3R4 [where A represents a direct bond between the S and N atoms or a lower alkylene group having 1 to 3 carbon atoms in the chain between the S and N atoms and R3 and R4 each independently represent hydrogen, lower alkyl, aryl or aryl(lower)alkyl or together with the nitrogen atom to which they are attached represent a five or six membered heterocyclic ring], aryl or a heterocyclic radical or R1 is -A1NR5.SO2R6 [where A1 is a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms, R5 is hydrogen or lower alkyl and R6 is lower alkyl, halo(lower)alkyl or aryl] and R2 is lower alkyl, halo(lower)alkyl or aryl. The compounds possess alpha 2-adrenoceptor antagonistic activity in warm blooded animals.