New aryl-substd. hydroxamic acid and N-hydroxy-lactam cpds. - lipoxygenase and/or cyclo:oxygenase inhibitors e.g. as analgesic, antiinflammatory, antipyretic and antiallergic agents

摘要

Cpds. of formula (I) and salts are new. Ar-(L-Ar')q-(X)k-(Y)p-Q (I) Where k, p and q each=0 or 1, provided that when k=1 then p=1; Ar=(i) naphthyl, tetrahydronaphthyl or pyridyl, all opt. substd. by 1 or more of 1-4C alkyl, haloalkyl or alkoxy, halogen, NO2, NH2, carboxy, 1-4C alkoxycarbonyl or OH, or (ii) phenyl, opt. substd. as in (i) or by phenyl, itself opt. substd. as in (i); L=-(CH2)r- (r=1-4), -O-, -CH2O-, -CH2S-, -OCH2-, -CONH-, -NHCO-, -CO- or -CH2NH-; Ar'=phenylene, thienylene or pyridylene, all opt. substd. as in (i); X=O, S or CO, provided that at least 1 atom. separates CO from any CO gp. in Q (below); Y=1-10C alkylene or alkenylene; Q=1-hydroxy-1,3-dihydro-imidazol-2-one or a gp. of formula (II) or (III); m=O and n=1 or m=1 and n=O; when n=1: R1 and R2 each=H or 1-4C alkyl, or R2 may also be 5-7C cycloalkyl; when m=1: R1=H, 1-4C alkyl, COR3 or a value of Ar, and R2=H, 1-4C alkyl, NH2, 1-4C alkylamino, di(1-4C alkyl)amino; 5-7C cycloalkylamino, 5-7C cycloalkyl (1-4C alkyl)amino; anilino, N-1-4C alkyl-anilino or a value of Ar; R3=1-4C alkyl (opt. substd. by carboxy or 1-4C alkoxycarbonyl) or -NR4R5; R4=H or 1-4C alkyl; R5=H, 1-4C alkyl or phenyl opt. substd. by substit(s)., as in (i); and Z=2-5C alkylene in which a C atom may be replaced by a heteroatom.