| 摘要 |
<p>-purinyl)-beta-D-ribofuranuronic acid thioamides (I) are new. They are esp. of formula (Ia), where R1 = H, 1-6C alkyl (opt. monosubstd. by an OH, SH or NR4R5), 3-7C alkenyl, 3-7C alkynyl, 3-7C cycloalkyl, (3-7C)cycloalkyl-(1-3C)alkyl, Ph (opt. mono-, di- or tri-substd. by F, Cl, Br, 1-4C alkyl, 1-4C alkoxy, OH, SH, 1-4C alkylthio, 1-4C alkylsulphonyl or SO2NR4R5), Ph-(1-6C)alkyl (opt. mono- or di-substd. in the ring as for Ph, and opt. substd. in the 1l6C alkylene chain by an OH), Ph-(3-7C)alkenyl (opt. ring substd. as for Ph), 5- or 6-membered monocyclic heteroaryl either contg. 1 or 2 N atoms or contg. 1O or 1S and opt. 1N atom, or 5l or 6-membered monocyclic heteroaryl-(1-5C)alkyl (the heteroaryl being similarly defined and the 1-5C alkylene being opt. substd. by an OH); R2 = H, 1-4C alkyl or 3-6C cycloalkyl; R3 = H or 1-4C alkyl; R4, R5 = H or 1-4C alkyl.S 28cpds. (I) are specifically claimed, including 1'-deoxy-1'-(6-(3-pentyl)amino -9-purinyl)-beta- D-ribofuranuronic acid N-ethylamide.</p> |
