发明名称 N- NAPHTHOYLGLYCINE DERIV ATIVES
摘要 Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications. The derivatives are of the formula <CHEM> (where R<1> is hydrogen lower alkyl, lower alkenyl or phenylmethyl, R<2> is hydrogen or lower alkyl and R<3>, R<4> and R<5> are hydrogen or specified substituents) and therapeutically acceptable salts of the compounds wherein R<2> is hydrogen. Certain intermediate aminoacids useful in the preparation of the above mentioned derivatives also have aldose reductive inhibiting effects.
申请公布号 MY8700627(A) 申请公布日期 1987.12.31
申请号 MY19870000627 申请日期 1987.12.30
申请人 AYERST MCKENNA & HARRISON INC. 发明人 SESTANI KAZIMIR;ABRAHAM NEDUMPARAMBIL;ABRAHAM;BELLINI FRANCESCO;TREASURYWALA ADI;HUMBER LESLIE;HUMBER LESLIE GEORGE
分类号 C07C327/48;A61K31/165;C07C63/72;C07C65/24;C07C69/94;C07C233/12;C07C327/38 主分类号 C07C327/48
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