| 摘要 |
N-(2-substituted alkyl)-N'-[(imidazole-4-yl)alkyl]guanidines having formula (1), wherein m is 1, 2 or 3; n is 2 or 3; X is a) S, O or CH2, and Y is a R substituted diphenylmethyl group or (10,11-dihydro)5H-dibenzo-[a-d]-cycloheptene-5-yl group, or is b) formula (II), wherein Y1 is a R-substituted phenyl group and Y is also a R-substituted phenyl group in that Y and Y1 need not be substituted simultaneously or Y is a R-substituted benzyl group, or is c) =CH-, and Y is a R-substituted diphenylmethylidenyl group or (10,11-dihydro)-5H-dibenzo-[a,d]-cycloheptene-5-ylidene group, R is H, alkyl, alkoxy halogen and/or trihalogen methyl, with the understanding that from all the appropriate phenyl rings one or more may be substituted by a R-substituted heterocyclic aromatic ring and their addition salts, with activity against heart failures and allergic conditions. |
