发明名称 |
Phenylpiperazine derivatives and their acid addition salts |
摘要 |
A phenylpiperazine derivative according to the present invention has the following general formula [I]: <IMAGE> [I] wherein R1, R2 and R3 are independently hydrogen or alkoxy group having 1 to 3 carbon atoms, or R1 and R2 or R2 and R3 together with carbon atoms to which they are attached form -O(CH2)mO- wherein m is an integer of 1 to 3, or either R1 or R2 is amine residue selected from the group consisting of -NH2 , -NHSO2CH3, -NHCOCH3 and -NHCONH2 and the other is hydrogen or alkoxy group of 1 to 3 carbon atoms and R3 is hydrogen; R4 and R5 are independently hydrogen or alkyl group of 1 to 3 carbon atoms; Y is -CO- or -SO2- provided that at least one of R1 and R2is not hydrogen when Y is -CO-; and n is an integer of 2 to 4. An acid addition salt of the phenylpiperazine derivative having the general formula [I] is included in the present invention. The phenylpiperazine derivative as well as its acid addition salt according to the present invention have the ability to reduce the blood pressure.
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申请公布号 |
US4716161(A) |
申请公布日期 |
1987.12.29 |
申请号 |
US19850719456 |
申请日期 |
1985.04.03 |
申请人 |
MITSUBISHI CHEMICAL INDUSTRIES LIMITED |
发明人 |
FUKAMI, HARUKAZU;KIKUMOTO, RYOJI;NAKAO, KENICHIRO;NITTA, ISSEI;INOUE, SHINYA |
分类号 |
C07D239/96;C07D285/32;C07D491/04;C07D491/056;C07D513/04;(IPC1-7):A61K31/54;C07D417/06 |
主分类号 |
C07D239/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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