| 摘要 |
1. Claims for the Contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Bicyclo (3.2.1.) octane-3-carboxylic acid derivatives, having the following general formula : see diagramm : EP0130882,P8,F2 in which : R represents a straight- or branched-chain lower alkyl radical Z represents a group OX in which X is hydrogen or an alkaline metal, or Z may also represent a group see diagramm : EP0130882,P8,F3 in which R1 and R2 , which may be the same or different, are hydrogen or a lower alkyl radical. 1. Claims for the Contracting State : AT Process for preparing Bicyclo (3.2.1.) octane-3-carboxylic acid derivatives, having the following general formula : see diagramm : EP0130882,P8,F4 in which : R represents a straight- or branched-chain lower alkyl radical Z represents a group OX in which X is hydrogen or an alkaline metal, or Z may also represent a group see diagramm : EP0130882,P8,F6 in which R1 and R2 , which may be the same or different, are hydrogen or a lower alkyl radical, comprising converting methyl 8-oxo-bicyclo (3.2.1.) octane-3-carboxylate having the formula : see diagramm : EP0130882,P8,F8 to an acid of the formula see diagramm : EP0130882,P9,F1 reacting the acid of the formula (III) with a strong base to give an intermediate organometallic compound having the formula see diagramm : EP0130882,P9,F2 in which B is an alkaline metal and, by action of an alkyl halide R-X in which R has the aforedisclosed meanings, converting compound (IV) to a compound of the formula (I) in which Z is OH, and preparing according to conventional methods the compounds of the formula (I) in which Z is other than OH. |
