| 摘要 |
A novel alpha interferon analogue, lacking a diaminopeptidase site at positions 22-23, may be expressed intact in hosts whose primary proteolytic activity against the natural species is at that site. A preferred host is a Saccharomyces cerevisiae strain carrying the PEP 3-4 mutation. The analogue has a Ser, Thr, Asn, Gln or Gly at position 22. |
