| 摘要 |
<p>A dosage form (20) for delivering a beneficial drug formulation (26) to an environment of use, comprising: a) a wall (22) comprising at least in part a composition permeable to the passage of fluid and substantially impermeable to the passage of a drug formulation (26) which wall surrounds and defines; b) a compartment (25); c) a dosage amount of a beneficial drug formulation in the compartment; and d) exit means (23) in the wall of the dosage form that connects compartment (25) with the exterior of the dosage form for delivering the drug formulation (26) from the dosage form; characterised by e) means for producing a biologically acceptable gas (27) in the compartment, said means comprising a pharmaceutically acceptable gas release rate controlling means (28); characterised by c) a dosage amount of an anti-inflammatory drug selected from an acylcarboxylic acid or enolic acid anti-inflammatory drug in the compartment (25); and by d) means (27) for producing gaseous carbon dioxide in the compartment, said means comprising a polymeric film (28) surrounding a member selected from a carbonate and bicarbonate.</p> |
