| 摘要 |
<p>PURPOSE:To facilitate the hydrolysis of a glycylamide bond existing in a hydrophobic solid and stable in normal state, by converting the bond to quaternary ammonium with ethylene oxide or propylene oxide. CONSTITUTION:A glycylamide group of formula I (R1, R3, R5 are H or lower alkyl; R2 and R4 are ordinary substituent group) is converted to a quaternary ammonium acetamidomethyl group having hydroxyethyl group of formula II (R6 and R7 are same as R1) by contacting with an oxirane compound such as ethylene oxide, propylene oxide, etc., (a liquid mixture of corresponding halohydrin compound and an alkali metal hydroxide may be used in place of the oxirane compound). The produced group is made to contact with water and converted to ammonium hydroxide salt under basic condition and, at the same time, the amide group is allowed to autohydrolysis. The reaction can be used for the removal of protecting group from an amino compound or the synthesis of polymer.</p> |
