| 摘要 |
PURPOSE:To improve the purity of crude ibuprofen delivered from a reaction process, to a level usable as a drug such as antipyretic, etc., in high efficiency with simple operation, by contacting the crude ibuprofen with an inorganic oxide such as silica having a specific surface area. CONSTITUTION:Crude ibuprofen is purified by contacting with one or more kinds of inorganic oxides selected from the oxides of Si, Al and Mg and having a specific surface area of >=50m<2>/g. The amount of the inorganic oxide is usually 1-50wt% based on the crude ibuprofen. The contact is carried out by dissolving the crude ibuprofen in a solvent (hexane, toluene, etc., preferably a solvent having low boiling point) and contacting the solution with the inorganic oxide at room temperature-150 deg.C, preferably under heating and refluxing the solvent. There is no particular restriction in the pressure of the contacting process provided that the reaction system keeps liquid phase at the treating temperature under the pressure. The inorganic oxide is preferably those having solid acid activity.
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