发明名称 |
Temperature sensitive strain of bovine viral diarrhoea virus |
摘要 |
Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.
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申请公布号 |
US4714678(A) |
申请公布日期 |
1987.12.22 |
申请号 |
US19860871732 |
申请日期 |
1986.07.31 |
申请人 |
SMITHKLINE-RIT |
发明人 |
DELGOFFE, JEAN-CLAUDE;LOBMANN, MICHELE;ZYGRAICH, NATHAN |
分类号 |
A61K39/12;C12N7/06;(IPC1-7):C12N7/00 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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