| 摘要 |
PURPOSE:To obtain a compound useful as a synthetic intermediate for dyes in heat- and pressure-sensitive paper, xanthene based dyes, fluorescent dyes, etc., by subjecting an aminophenol and aldehyde to N-alkylating reaction under specific condition and further reacting the resultant product with an aldehyde. CONSTITUTION:One mol aminophenol is reacted with 0.8-1.5mol aldehyde, expressed by the formula R.CHO (R is 1-5C alkyl) in the presence of a catalyst, e.g. platinum supported on active carbon and/or Pd, in an aliphatic alcoholic solvent at 0-80 deg.C under pressure of hydrogen to give an N-monoalkyl- substituted aminophenol expressed by formula I, which is subsequently reacted with 0.8-2.5mol aldehyde expressed by the formula R'.CHO (R' is 1-5C alkyl) to afford the aimed substance expressed by formula II. The aldehyde is introduced into the reaction system at <=0.1mol/min rate based on 1mol aminophenol and/or compound expressed by formula I. EFFECT:Side reaction is suppressed and the aimed substance is obtained in high selectivity without any problem in corrosion of materials. |
