发明名称 IMPROVED ANTITUMOUR AGENTS, THEIR PREPARATION AND PROCESS TO ENHANCE THE ACTIVITY OF ANTITUMOUR AGENTS
摘要 PCT No. PCT/FR83/00036 Sec. 371 Date Oct. 26, 1983 Sec. 102(e) Date Oct. 26, 1983 PCT Filed Feb. 25, 1983 PCT Pub. No. WO83/02946 PCT Pub. Date Sep. 1, 1983.According to the invention, the antitumor agent such as daunorubicin and a well-defined quantity of a bifunctional crosslinking agent, such as glutaraldehyde, are brought together. A form of polymeric product is obtained, which is insoluble in aqueous media but which, on being resuspended in an aqueous medium in the absence of glutaraldehyde, gradually releases the antitumor agent in a soluble form, preserving its antitumor activity. Improvement of the conditions of treatment with antitumor agents.
申请公布号 DE3374411(D1) 申请公布日期 1987.12.17
申请号 DE19833374411 申请日期 1983.02.25
申请人 INSTITUT PASTEUR 发明人 RELYVELD, EDGAR HANS
分类号 C07H1/00;A61K45/08;C07D213/71;C07H15/252;(IPC1-7):C07H15/24;A61K31/70 主分类号 C07H1/00
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