| 摘要 |
<p>Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein, R1 is hydrogen or alkyl; R2 is alkyl or R1 and R2 are polymethylene; R3 is hydrogen, hydroxy, alkoxy, acyloxy; R4 is hydrogen or R3 and R4 are a bond; R5 is hydrogen, optionally substituted alkyl, alkenyl, optionally substituted amino, optionally substituted aryl or heteroaryl, carboxy, alkoxycarbonyl or aminocarbonyl; R6 is hydrogen or alkyl or R5 and R6 together are -CH2-(CH2)n-Z-(CH2)m-, wherein m and n are 0 to 2, m + n is 1 or 2, Z is CH2, O, S, NR; R is hydrogen, alkyl, alkanoyl, phenyl-alkyl, naphthycarbonyl, phenylcarbonyl, benzylcarbonyl, or heteroarylcarbonyl; X is O, S or R5, R6, X and N together are tetrahydroisoquinolinone or tetrahydroisoquinolinthione. These compounds show anti-hyper tensive activity.</p> |
