发明名称 |
RADIOACTIVE LIGATED RHENIUM COMPOUNDS AND METHODS OF PRODUCTION AND USE |
摘要 |
A sterile pyrogen free Re<1><8><6> or Re<1><8><8> radiopharmaceutical is prepared by reducing radioactive perrhenate in the presence of a bone seeking ligand to form a solution including complexed Re-ligand compound together with impurities such as uncomplexed perrhenate, ReO2 and free ligand. The radiopharmaceutical is obtained by a low pressure purification method. The solution is added to a separation column (12), preferably an ion exchange column, and a first portion is eluted and discarded. The radiopharmaceutical is collected in a second eluted portion defined as having 25-85% of the activity of the Re on the column, less than 10% unligated perrhenate and less than 1% ReO2. This can be used as is to image and treat metastatic bone lesions. A simple kit is also disclosed. |
申请公布号 |
AU7376887(A) |
申请公布日期 |
1987.12.17 |
申请号 |
AU19870073768 |
申请日期 |
1987.06.03 |
申请人 |
UNIVERSITY OF CINCINNATI, |
发明人 |
EDWARD DEUTSCH;HARRY R. MAXON;MAREN F. LIBSON;ALAN KETRING |
分类号 |
C07F13/00;A61K51/00;A61K51/12;G21G4/08 |
主分类号 |
C07F13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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