| 摘要 |
<p>Compounds of formula 1 as their racemic mixtures or optical isomers are calcium entry antagonists useful for treating hypertension, congestive heart failure, angina, and vasospastic disorders: <CHEM> wherein n is an integer from 1 to 4; R1 and R2 are lower alkyl; R3 is lower alkyl or alkoxyalkyl; A is alkylene of two to eight carbon atoms; X1 and X2 are each independently -NO2, -CF3, CH3O-, -CN, -H, lower alkyl or halo; Y is -O-, -S-, -S(O)-, or -S(O)2-; and R is H or R' wherein R' is lower alkyl, cycloalkyl, alkoxyalkyl, cycloalkyloxy-alkyl, alkoxycycloalkyl, acyl, or saturated or unsaturated 5- or 6-membered heterocyclyl optionally substituted with lower alkyl or alkoxy, wherein the heteroatom is one oxygen atom.</p> |
