| 摘要 |
PURPOSE:An antitumor agent having improved cytocidal and antitumor effects, comprising 2,3,6-trichloronaphthazarin, etc., as active ingredients. CONSTITUTION:An antitumor agent comprising a compound shown by formula I [ring A is group shown by formula II, formula III, formula IV or formula V (numbers 1-4 show positions of substituent groups R1-R4, R1-R3=Cl and R4=H; R1, R2 and R4=Cl and R3=H; R1 and R2=OCH3, R3=Cl and R4=H; R1 and R2=OCH3, R3=H and R4=Cl; R1-R3=OCH3 and R4=H; R1, R2 and R4=OCH3 and R3=H) as an active ingredient. 2,3,6-Trichloronaphthazarin compound having antitumor action wherein ring A in the formula I is group shown by formula II, R1-R3 are Cl and R4 is H is obtained by condensing 2,3- dichloromaleic anhydride with 2,3,6-trichloronaphthazarin in the presence of anhydrous AlCl3 and NaCl under heating. This compound is reacted with CH3ONa to give a compound shown by formula VI and a compound shown by formula VII of the compound shown by formula I, having antitumor action.
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