Oxodiazine compounds and pharmaceutical compositions thereof

摘要

An oxodiazine compound of the formula: <IMAGE> or a pharamceutically acceptable acid addition salt thereof, wherein each of R1 and R2 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy, phenyl-C1-4 alkyl-oxy which may be optionally substituted by at least one substituent selected from the group consisting of halogen, C1-4 alkyl and C1-4 alkoxy on the phenyl nucleus, or phenyl which may be substituted by at least one substituent selected from the group consisting of halogen, C1-4 alkyl and C1-4 alkoxy on the phenyl nucleus; X is -S-, -CH=N- or -C(R3)=C(R4)-, where each of R3 and R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy or phenyl-C1-4 alkyl-oxy which may be optionally substituted by at least one substituent selected from the group consisting of halogen, C1-4 alkyl and C1-4 alkoxy on the phenyl nucleus; and one of A and B is oxygen, sulfur or -NH- and the other is -C(R5) (R6)-, where each of R5 and R6 is hydrogen or C1-4 alkyl. Such compounds are useful as antithrombotic agents, antianginal agents, coronary circulation improving agent, cerebral circulation improving agents, peripheral circulation improving agents, analgesics and antiinflammatory agents.