| 摘要 |
PURPOSE:To provide the titled composition containing nicardipine hydrochloride, an organic acid and a water-soluble polymeric compound. CONSTITUTION:The long-acting nicardipine hydrochloride composition can be produced by compounding (A) 1pt. of nicardipine hydrochloride [2,6- dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-di-carboxylic acid 3-methyl ester 5-beta-(N-benzyl-N-methylamino)ethyl ester hydrochloride], (B) >=0.5pts. of an organic acid (e.g citric acid, tartaric acid, succinic acid, adipic acid, etc.) and (C) 0.5-3pts. of a water-soluble polymeric compound (e.g. methylcellulose, hydroxypropyl cellulose, etc.). The dissolution liquid impregnated in the drug is maintained within a low pH region by the compounding of the above components. Consequently, the solubility of nicardipine hydrochloride is improved and the high solubility is continued. The long-acting drug can be easily prepared based on the above mechanism.
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