| 摘要 |
The invention relates to penicillin derivatives of Formula I, and a method of synthesis; the derivatives having high antimicrobial activity against gram-positive and gram-negative microorganisms. <IMAGE> FORMULA I R is selected from the group consisting of <IMAGE> +TR <IMAGE> R1 is selected from the group consisting of hydrogen and a hydroxyl group; R2 is selected from the group consisting of hydrogen, an alkaline metal, and a carboxy protective group; R3 is selected from the group consisting of hydrogen, a lower alkyl, and a phenyl residue; R4, R5, and R6 are each selected from the group consisting of hydrogen, a halogen, a lower alkyd, and a lower alkoxy group; A is selected from the group consisting of oxygen and a N-(lower alkyl) residue; and n is 0 or 1.
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