| 摘要 |
PURPOSE:To readily obtain a cinnamic acid derivative in high yield and purity in a short time without coloring of a reaction solution, etc., by reacting a benzaldehyde derivative with a malonic acid derivative in the presence of a specific aminopyridine derivative as a catalyst. CONSTITUTION:A benzaldehyde derivative expressed by formula I {R<1> and R<2> are H, OH, nitro, lower alkyl, lower alkoxy, -NR<3>R<4> [R<3> and R<4> are H, (halogen-substituted) lower alkyl, etc.}, etc. is reacted with a malonic acid derivative expressed by formula II (R<5> is H or lower alkyl) in an inert solvent in the presence of an aminopyridine derivative catalyst expressed by formula III (R<6> and R<7> are R<5> or together with N form a 5- or 6-membered saturated heterocyclic ring), e.g. 4-dimethylaminopyridine, etc., at 0-200 deg.C for 1-15hr to afford the aimed compound expressed by formula IV. EFFECT:The reaction solvent and catalyst are readily recovered and regenerated and working environment is good. Industrial massproduction can be carried out without requiring deodorizing equipment. USE:An intermediate for synthesizing medicines. |
