| 摘要 |
PURPOSE:To remove isophorone as a by-product simply and to obtain the titled compound useful as a raw material for drugs and agricultural chemicals from inexpensive raw material in high purity and in high yield, by reacting O-toluic acid with acetic acid or acetone, hydrogenating the prepared crude reaction product and distilling the hydrogenated substance. CONSTITUTION:O-Toluic acid and acetic acid or acetone as raw materials are reacted in a gaseous phase to give crude O-methylacetophenone. Then, the crude reaction product is firstly hydrogenated and then distilled to give the aimed compound. The hydrogenation treatment is carried out in the presence of 1-20wt%, preferably 5-10wt% based on the crude reaction product of a catalyst such an nickel, palladium, etc., under hydrogen pressure at normal pressure - 100atm., preferably 1-about 50atom. at room temperature - 100 deg.C, preferably 20-50 deg.C. The catalyst is removed from the crude reaction product having finished the hydrogenation treatment and the crude reaction product is distilled. The molar ratio of the O-toluic acid as the raw material to acetic acid or acetone fed is preferably 1:1-10.
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