| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is alkyl; R<2> is H, alkyl, acyl, aryl, etc.; R<8> is H or (protected) carboxy; Q is group of formula II (R<3>-R<5> are H or alkyl) or E (E is 5-7-membered heterocyclic group which may have substituent group); Z<-> is anion; m is 0-3; n is 0-10; A is single bond, CO-NH or 5-7-membered heterocyclic group; B is single bond or 5-7-membered hetero cyclic group; Y is O, S, (substituted) NH, group of formula III (X is O or S), etc.] or its salt. EXAMPLE:(2RS)-3-octadecyloxy-2-(2-thiazolyloxy)propyl 2-trimethylammonioethyl phosphate. USE:It has platelet activating factor antagonistic action and is useful as an antishock agent, antithrombogenic agent, anti-asthmatic agent and anti-allergic agent. PREPARATION:For example, the compound of formula IV is made to react with the compound of formula V and the resultant compound of formula VI is made to react with the amine of formula VII to obtain the corresponding compound of formula I.
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