HTLV-III(LAV) Envelope peptides.

摘要

Synthetic peptides containing the epitopic sequence HTLV env (578-608) of the formula: W-X-Ala-Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gl y-Ile-Trp- Gly-Cys-Ser-Gly-Lys-Leu-Ile-Cys-Thr-Thr-Ala-Val-Y-Z (I) wherein W is H-, Cys- or Tyr-, X is a bond or a sub-sequence of one or more amino acids starting from the carboxyl terminus of HLTV-III env (557-577); Y is a bond or a sub-sequence of one or more amino acids starting from the amino terminus of HTLV-III env (609-641); and Z is -OH, -NHÊ -Cys-NHÊ, provided however that one of X and Y is a bond, are disclosed which peptides are useful as reagents in immunoassays for detection of AIDS antibodies, as immunogens for eliciting polyclonal or monoclonal antibodies against AIDS virus env protein and as components in an AIDS vaccine.