5-flurorouracil derivatives.

摘要

This invention relates to a 5-fluorouracil derivative represented by the formula <CHEM> wherein R<y> is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group <CHEM> wherein R<1> and R<2> are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group R<x>OCO- on the phenyl ring, or a group -(A)nB, R<x> fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R<1> is a hydrogen atom or acyl group, R<2> is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition.