Carbapenem antibiotics

摘要

Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula <IMAGE> in which A represents cyclopentylene, cyclohexylene or C2-C6 alkylene optionally substituted by one or more C1-C4 alkyl groups and <IMAGE> represents a quaternized nitrogen-containing aromatic heterocycle. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives and novel intermediates utilized in these processes.