UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 6-AMINO-4-AMINO (SUSTITUIDO)-1,2-DIHIDRO-1-HIDROXI-2-IMINOPIRIMIDINA O SUS TAUTOMEROS

摘要

6-Amino 4-substd. amino 1-hydroxy 2-imino 1,2-dihydro pyrimidines of formula (I), in which R1 and R2 are alkyl or together form part of a ring, and their tautomers, for pharmaceutical use, are made by reacting a metallised deriv. of an amine of formula R1R2NH with 6-amino 4-halo 1-hydroxy 2-imino 1,2-dihydro pyrimidine in inert solvent e.g. dimethyl acetamide or DMSO, under reflux for 1-2 hours.