发明名称 |
Lyophilized hepatitis B vaccine |
摘要 |
Lyophilized preparation of hepartitis B vaccine, which comprises a purified hepatitis B virus surface antigen produced by a recombinant organism being capable of producing HBs antigen, which is adsorbed on aluminum gel in the lyophilized state in the presence of a stabilizer, said lyophilized preparation being prepared by the steps of adding an aluminum gel and a stabilizer to a purified recombinant-origin HBs antigen and lyophilizing the mixture. Said lyophilized preparation being able to be stably kept for a long period of time without losing its antigen titer and being useful for the prophylaxis of infection of hepatitis B virus.
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申请公布号 |
US4710378(A) |
申请公布日期 |
1987.12.01 |
申请号 |
US19850709705 |
申请日期 |
1985.03.08 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
OHTOMO, NOBUYA;MIZUNO, KYOSUKE;HAMADA, FUKUSABURO;MIZOKAMI, HIROSHI |
分类号 |
C12N15/09;A61K39/00;A61K39/29;C07K14/02;C12P21/00;C12R1/865;C12R1/91;(IPC1-7):A61K39/29 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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