| 摘要 |
PURPOSE:To obtain a preparation for ophthalmic administration, having high transferability to protomerite and useful for the remedy of inflammation of conjunctiva and ectocornea in ophthalmic field, by adding flurbiprofen (FP) to fat emulsion. CONSTITUTION:Soybean oil is mixed with phospholipid and FP [2-(2-fluoro-4- biphenylyl)propionic acid] or its derivative and, if necessary, with an additive such as emulsifying assistant, stabilizer, etc., at prescribed ratios. The mixture is heated to obtain a solution, homogenized to a W/O-type dispersion with a homogenizer, added with a prescribed amount of water and homogenized again to convert the dispersion to an O/W-type emulsion and obtain an FP- containing fat emulsion having average particle diameter of preferably <=1.0mu (particle size distribution of 0.1-1.0mu). The composition of the emulsion is preferably 0.01-1(W/V)% FP, 1-20% soybean oil and 5-30pts. of phospholipid based on 100pts. of soybean oil.
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