2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof

摘要

2-Phenylpropoionic acid ester of Formula (I): (I) wherein R represents p-nitrophenyl group, beta -naphthyl group or 2-( beta -naphthyl)ethyl group. Optical resolution of the above is carried out by preferential crystallization by seeding either one of the optical isomers into a super-saturated solution of a racemic modification thereof or a mixture of the optical isomers thereof. The efficiency of the optical resolution can be increased by optional addition of a recemizing agent comprising a strongly basic amine or an alcholate.