DERIVATIVES OF ALKYLPHENYL, ALKYL, ALKYL(OXY,THIO) PHENYL AMINE

摘要

Compounds of the formula:- and their salts, wherein R is -NO2, -NH2 or -NHSO2R<1> where R<1> is a C1-C4 alkyl group; R is-NO2, -NH2 or R<3> where R<3> is-NHSO2(C1-C4 alkyl) or -CONR<4>R<5> where R<4> and R<5> are each independently H or C1-C4 alkyl or together with the nitrogen atom to which they are attached represent a 1-pyrrolidinyl, piperidino, morpholino or N-methylpiperazin-l-yl group; with the proviso that when one of R and R is -NO2, then the other is not -NH2; X is O, S or a direct link; Y is an ethylene group optionally substituted by a methyl group; "alk" is an ethylene, trimethylene or tetramethylene group, "alk" being optionally substituted by a methyl group; R is C1-C4 alkyl; and R<2> is H, halo, CF3 or C1-C4 alkyl. The compounds of the formula (A) in which R is -NHSO2R<1> and R is R<3> are antiarrhythmic agents. The remaining compounds of the formula (A) are synthetic intermediates.