发明名称 |
ASSAYS AND ANTIBODIES FOR N-myc PROTEINS |
摘要 |
Methods and compositions for identifying patients suffering from cancer, particularly neural and neuroendocrine cancers. It has been found that the protein expression product of the human N-myc photo-oncogene may be detected in certain biological specimens, particularly tissue specimens and sputum samples. By obtaining immunogenic N-myc polypeptides, either synthetically or by isolation from a natural source, antibodies specific for the N-myc protein are obtained. Those antibodies may then be used in immunological techniques for detecting the presence of N-myc in the biological samples. In particular, the antibodies may be employed in immunohistochemical techniques to detect the N-myc protein in prepared tissue and sputum samples. |
申请公布号 |
WO8706940(A1) |
申请公布日期 |
1987.11.19 |
申请号 |
WO1987US01046 |
申请日期 |
1987.05.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;AMGEN |
发明人 |
SLAMON, DENNIS, J.;SOUZA, LAWRENCE, M. |
分类号 |
C12P21/02;A61K38/00;A61K39/00;A61K39/395;C07H21/04;C07K1/22;C07K7/06;C07K7/08;C07K14/00;C07K14/435;C07K14/82;C07K16/00;C07K16/32;G01N33/574;(IPC1-7):C07K7/06;C07K15/12;C07K7/10;C12N15/00;G01N33/53 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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