发明名称 |
BIODEGRADABLE CONTROLLED RELEASE AGENT COMPRISING A COPOLYMERISED, HYDROPHILIC POLYMER AND A WATER SOLUBLE MONOVINYL MONOMER |
摘要 |
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein. |
申请公布号 |
AU7266887(A) |
申请公布日期 |
1987.11.19 |
申请号 |
AU19870072668 |
申请日期 |
1987.05.07 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE, |
发明人 |
PATRICK P. DELUCA;FRANTISEK RYPACEK |
分类号 |
A61K47/34;A61K9/16;A61K9/26;A61K9/52;A61K47/32;A61K47/36;A61K47/42;B01J13/14;C08F2/22;C08F2/44 |
主分类号 |
A61K47/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|