| 摘要 |
PURPOSE:To provide a dermatic agent for external use by combining a glycyrrhizic acid compound having anti-inflammatory effect with a p- methoxycinnamic acid ester compound, thereby increasing the above effects without causing side effects. CONSTITUTION:A dermatic agent for externals use having excellent anti- inflammatory effect can be produced by compounding (A) one or more compounds selected from glycyrrhizic acid and its derivative (e.g. glycyrrhizic acid dicalcium salt, glycyrrhizic acid monoammonium salt, glycyrrhizic acid stearate, etc.) and (B) one or more kinds of p-methoxycinnamic acid ester compound of formula I-V (R<1> is 5-17C alkyl derived from saturated side-chain fatty acid; R<2> is 1-2C alkyl; R<3> is OCH3 substituted to ortho or para position). The amount of the component A in the whole dermatic agent is 0.001-5wt%, preferably 0.05-0.1wt%, and that of the component B is >=1/100pts.wt., preferably >=1pt.wt. per 1pt.wt. of the component A. |
