| 摘要 |
There is provided a novel drug delivery system which provides for intermittent drug delivery with readily adjustable intervals between drug delivery pulses. This is accomplished by providing a multilayer device in which layers of active drug (9) are readily expandable or erodable when contacted with the environment in which the drug is to be administered. The drug layer (9) is alternated with an inert layer (7) and a multiplicity of such layers (9, 7) are contained within a tube (1) impervious (10) to such environment but provided with an opening (3) into such environment. The multiplicity of such layers is driven along the length of such tube towards the opening (3). The interval between pulses is determined by the rate the layers are driven along the tube (1) and the sizes of the layers. The duration of the pulse is determined by the rate of expansion or dispersion of the active layer into the environment, wherein the rate of expansion or dispersion is greater than the rate the layers are driven along the tube. Osmotic expansion is the preferred means of driving force as shown by figure 5 with osmotic chamber (14), osmotic fluid inlet (13) and piston (15). |
